MAITAKE MUSHROOMS (GRIFOLA FRONDOSA)

General

Cronkleton, E. (2017, October 12). Maitake mushroom: Risks, benefits, and more. Healthline. Retrieved November 14, 2022, from https://www.healthline.com/health/food-nutrition/maitake-mushroom#TOC_TITLE_HDR_1  

Camilleri E, Blundell R, Baral B, Karpiński TM, Aruci E, Atrooz OM. Unveiling the full spectrum of maitake mushrooms: A comprehensive review of their medicinal, therapeutic, nutraceutical, and cosmetic potential. Heliyon. 2024 Apr 26;10(9):e30254. doi: 10.1016/j.heliyon.2024.e30254. PMID: 38707308; PMCID: PMC11068609.

He X, Wang X, Fang J, Chang Y, Ning N, Guo H, Huang L, Huang X, Zhao Z. Polysaccharides in Grifola frondosa mushroom and their health promoting properties: A review. Int J Biol Macromol. 2017 Aug;101:910-921. doi: 10.1016/j.ijbiomac.2017.03.177. Epub 2017 Mar 31. PMID: 28366857.

Wu JY, Siu KC, Geng P. Bioactive Ingredients and Medicinal Values of Grifola frondosa (Maitake). Foods. 2021 Jan 5;10(1):95. doi: 10.3390/foods10010095. PMID: 33466429; PMCID: PMC7824844.

Immune Support

Guggenheim, A. G., Wright, K. M., & Zwickey, H. L. (2014). Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology. Integrative medicine (Encinitas, Calif.), 13(1), 32–44.

Aguilera-Braico DM, Balogh GA. CD3Ɛ immune restorative ability induced by Maitake Pro4x in immunosupressed BALBc mice. BMC Res Notes. 2022 Sep 23;15(1):307. doi: 10.1186/s13104-022-06201-1. PMID: 36138418; PMCID: PMC9502923.  

Kubo K, Nanba H. The effect of maitake mushrooms on liver and serum lipids. Altern Ther Health Med. 1996 Sep;2(5):62-6. PMID: 8795938. 

Camilleri E, Blundell R, Baral B, Karpiński TM, Aruci E, Atrooz OM. Unveiling the full spectrum of maitake mushrooms: A comprehensive review of their medicinal, therapeutic, nutraceutical, and cosmetic potential. Heliyon. 2024 Apr 26;10(9):e30254. doi: 10.1016/j.heliyon.2024.e30254. PMID: 38707308; PMCID: PMC11068609.

Alonso E. Noelia, Ferronato M. Julia, Fermento M. Eugenia, Gandini N. Ariel, Romero A. López, Guevara J. Alejandra, Facchinetti M. Marta, Curino A. Carlos Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells. Oncotarget. 2018; 9: 23396-23412. Retrieved from https://www.oncotarget.com/article/25174/text/

Heart Health

Fukushima, M., Ohashi, T., Fujiwara, Y., Sonoyama, K., & Nakano, M. (2001). Cholesterol-Lowering Effects of Maitake (Grifola frondosa) Fiber, Shiitake (Lentinus edodes) Fiber, and Enokitake (Flammulina velutipes) Fiber in Rats. Experimental Biology and Medicine, 226(8), 758–765. https://doi.org/10.1177/153537020222600808

Ding, YY., Lan, J., Wang, Y. et al. Structure characterization of Grifola frondosa polysaccharide and its effect on insulin resistance in HFD-fed mice. npj Sci Food 9, 3 (2025). https://doi.org/10.1038/s41538-024-00359-7

Sato M, Tokuji Y, Yoneyama S, Fujii-Akiyama K, Kinoshita M, Chiji H, Ohnishi M. Effect of dietary Maitake (Grifola frondosa) mushrooms on plasma cholesterol and hepatic gene expression in cholesterol-fed mice. J Oleo Sci. 2013;62(12):1049-58. doi: 10.5650/jos.62.1049. PMID: 24292357.

Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo). 1987 Oct;33(5):341-6. doi: 10.3177/jnsv.33.341. PMID: 3443885.

Kubo K, Nanba H. Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I. Biol Pharm Bull. 1997 Jul;20(7):781-5. doi: 10.1248/bpb.20.781. PMID: 9255420.

Joint Support

Mallard B, Leach D. N, Wohlmuth H, Tiralongo J. Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake. PLoS ONE. 2019;14(11).

Erjavec I, Brkljacic J, Vukicevic S, Jakopovic B, Jakopovich I. Mushroom Extracts Decrease Bone Resorption and Improve Bone Formation. Int J Med Mushrooms. 2016;18(7):559-69. doi: 10.1615/intjmedmushrooms.v18.i7.10. PMID: 27649725.

Weight Support

Horio H, Ohtsuru M. Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats. J Nutr Sci Vitaminol (Tokyo). 2001 Feb;47(1):57-63. doi: 10.3177/jnsv.47.57. PMID: 11349892.