The Balance Blend for Women’s Health

April 24, 2024 | Dr. Silvana Jakupovic, ND

In today's fast-paced world, achieving balance in our health and wellness routines has become more important than ever, particularly for women. Enter the 4 Mushroom Blend (Balance Blend) from Eversio Wellness, a meticulously crafted that may support women's health through the power of medicinal mushrooms. 

This functional mushroom blend harnesses the unique properties of Reishi, Lion's Mane, Maitake, and Shiitake mushrooms to offer a holistic approach to wellness. It's designed not only to strengthen the immune system and improve cognitive function but also to relieve stress, enhance sleep quality, and may even provide hormonal support. The Balance Blend represents a convergence of ancient wisdom and modern science, providing a natural, potent solution for those seeking harmony in their health regimen​.

4 mushroom balance blend powder

The Benefits of Reishi Mushrooms

Reishi mushrooms, recognized as Lingzhi in traditional Chinese medicine, belong to the Ganoderma lucidumspecies. Their health-boosting properties stem from active compounds like polysaccharides, triterpenoids, and peptidoglycans, known to enhance immune function, reduce inflammation, and combat oxidative stress. Traditionally, they bolster immunity, encourage longevity, and improve wellness.

Reishi for the Immune System

Medicinal mushrooms like Reishi are celebrated for their role as natural biological response modifiers that enhance immune functions critical for women's health [1]. These mushrooms support the body's defence mechanisms by activating key immune cells and promoting cytokine production.  

Their immunomodulatory benefits, confirmed through research in various demographics, including cancer patients and healthy individuals, are exceptionally vital for women, who may face unique health challenges requiring robust immune support [2,3]. Strengthening immune health is integral to women's overall well-being, addressing issues from stress to hormonal balance. 

Reishi for Sleep Support 

Reishi mushrooms have long been admired for their tranquillizing effects, promoting restorative sleep, which is essential for overall health [4]. Sleep is pivotal, as inadequate rest is linked to various health issues, including cardiovascular diseases and diabetes [4]. 

Animal studies suggest that Reishi enhances sleep by increasing sleep-promoting neurotransmitters and positively affecting gut microbiota, which is connected to sleep quality via the gut-brain axis [4]. This makes Reishi a promising natural option for improving sleep through serotonin and microbiota pathways, underscoring its importance in women's health by addressing sleep, a fundamental pillar of well-being. 

Reishi Mushrooms for Hormones

Research has unveiled that extracts from Reishi mushrooms may mimic estrogen, the key female hormone, by binding and activating human estrogen receptors [5]. This action is particularly beneficial for women undergoing menopause, a time marked by a natural decrease in estrogen production that can lead to a variety of physical and mental health challenges, including mood swings, depression, and cognitive issues [6,7]. 

Moreover, the shift from estradiol, the primary form of estrogen produced in the ovaries before menopause, to estrone, which is mainly produced in body fat post-menopause, underscores the need for interventions that can support this hormonal adjustment. Reishi mushrooms may address this need but also possess anti-androgenic properties, making them a powerful tool against conditions driven by male hormones, such as PCOS (Polycystic Ovary Syndrome), hirsutism (excess hair growth), acne, and certain types of cancers [8].  

Reishi may be effective in inhibiting testosterone and preventing its conversion into dihydrotestosterone (DHT), a more potent androgen linked to several conditions, including balding and acne [9]. Through these actions, Reishi mushrooms emerge as a versatile and beneficial component of women's health strategies, providing a natural option for balancing hormones and combating the symptoms and conditions associated with hormonal imbalances.

The Benefits of Lion’s Mane 

Historically celebrated in traditional Chinese and Japanese healing practices, Lion's Mane mushrooms were believed to bolster brain health and cognitive functions. Ancient writings often hailed them as natural enhancers of memory, focus, and mental clarity. As the search for natural health solutions grows, modern science is increasingly drawn to Lion's Mane, seeking to explore and validate its therapeutic benefits and uncover the rich history behind its use. 

Lion’s Mane for Brain Health

As women age, the decline in cognitive function becomes a notable concern. The maintenance of cognitive health is vital for women, particularly as they approach and navigate through menopause, a phase marked by significant hormonal changes that can impact mental acuity and memory. 

Lion’s Mane mushrooms contain hericenones and erinacines, compounds that promote neurogenesis (the formation of new brain cells), crucial for sustaining cognitive abilities [9]. Research has highlighted Lion’s Mane's potential to reverse age-related cognitive decline [9]. For example, an animal study demonstrated that these mushrooms may improve recognition memory, the ability to remember previously encountered objects or individuals, by enhancing neurogenesis in the brain's hippocampus, a region integral to memory and learning [9].

Furthermore, Lion’s Mane has shown neuroprotective effects, protecting brain cells from damage by beta-amyloid plaques associated with Alzheimer’s disease [10,11,12]. In clinical trials, individuals with mild cognitive impairment who took Lion’s Mane supplements showed significant cognitive improvement, highlighting its potential as a natural remedy for enhancing cognitive function in aging women, supporting their memory, and contributing to their overall quality of life as they age [13].

4 mushroom balance blend

The Benefits of Shiitake Mushrooms

Shiitake mushrooms are a celebrated and tasty edible fungus from East Asia with deep roots in Japan and China. These mushrooms have been intertwined with traditional medicine and culinary traditions for thousands of years, holding a place of honour in both fields. 

Shiitake for Heart Health

Research has highlighted the heart-healthy benefits of incorporating Shiitake mushrooms into one's diet, especially for managing cholesterol levels [14]. In a particular study, rats with high cholesterol that consumed a diet with 5% Shiitake mushroom fruiting bodies showed marked improvements in their cholesterol and lipid profiles. This included reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL) — the so-called "bad" cholesterol [14]. 

Notably, these benefits were achieved without negatively impacting other vital blood parameters, like albumin and creatinine. They were accompanied by increased excretion of cholesterol and lipids, suggesting Shiitake mushrooms may aid cardiovascular health by facilitating the body's natural elimination of these substances [14].

Heart health is essential for women, who may face unique risks and manifestations of heart disease, especially as they age. Women's heart health requires attention to factors like cholesterol management, as high cholesterol is a crucial risk factor for developing heart conditions. This risk becomes more pronounced with age and is further complicated by menopause, which can lead to changes in blood lipid levels and increased cardiovascular risk.  

The findings from a human study, where participants consuming Shiitake mushroom bars showed a significant reduction in triglycerides, stress the importance of dietary choices in maintaining cardiovascular health [15]. Given that heart disease remains a leading cause of death for women, incorporating heart-healthy foods like Shiitake mushrooms into the diet could be a proactive step towards reducing risk factors associated with cardiovascular conditions.

The Benefits of Maitake Mushrooms

Maitake mushrooms, known colloquially as "Hen of the Woods" due to their resemblance to the ruffled plumage of a hen, are celebrated medicinal fungi with origins in Japan and various Asian regions. Further research into Maitake mushrooms has revealed their potential to support cardiovascular health, stabilize blood sugar levels, and mitigate inflammation. Maitake mushrooms thus represent a compelling subject within historical medicine and ongoing health research, offering potential natural solutions for various health concerns.

Maitake for PCOS (Polycystic Ovary Syndrome) 

A clinical trial in Japan explored the effectiveness of Maitake mushroom extract (MSX) in triggering ovulation in women with polycystic ovary syndrome (PCOS), comparing its success to that of the commonly used drug clomiphene citrate (CC). The research involved monitoring ovulation rates in 26 patients given MSX and 31 patients treated with CC [16]. 

The outcomes showed that MSX achieved an ovulation rate of 76.9% (20 out of 26 patients). In comparison, CC had a higher success rate of 93.5% (29 out of 31 patients), with the difference between the two not being statistically significant. 

However, for those who did not initially respond to either treatment alone, combination therapy was explored. Remarkably, all seven patients who did not ovulate with MSX alone and six out of eight patients who did not respond to CC alone succeeded in ovulating with the combination therapy [16]. These findings highlight that MSX and CC may both be viable options for inducing ovulation in PCOS patients, with combination therapy serving as an effective strategy for those not benefiting from single-agent treatment.

Medicinal Mushrooms for Women’s Health

The 4 Mushroom Blend (Balance Blend) from Eversio Wellness emerges as a natural, holistic approach to enhancing women's health, blending traditional medicine's ancient wisdom with modern science's precision. By incorporating Reishi, Lion's Mane, Maitake, and Shiitake mushrooms, this supplement offers a multifaceted strategy for bolstering immune health, cognitive function, and stress relief while potentially supporting hormonal balance and sleep quality. 

This comprehensive blend highlights the significance of natural dietary approaches in addressing the multifarious health challenges women face, particularly as they age. Recognizing the importance of heart health, cognitive function, and hormonal balance, the Balance Blend stands as a testament to the enduring efficacy of medicinal mushrooms in fostering overall well-being and harmony within the body's intricate systems.

 

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References

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[2] Lin, Z. B., & Zhang, H. N. (2004). Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. Acta Pharmacologica Sinica, 25(11), 1387-1395.

[3] Wang, S. Y., Hsu, M. L., Hsu, H. C., Lee, S. S., Shiao, M. S., & Ho, C. K. (1997). The anti-tumor effects of Ganoderma lucidum (Curt.: Fr.) P. Karst. (Ling Zhi, Reishi mushroom) (Aphyllophoromycetideae) polysaccharides are related to tumour necrosis factor-α and interferon-γ. Cryptogamie, Mycologie, 18(3), 191-195. 

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[5] Shimizu, K., Miyamoto, I., Liu, J. et al. Estrogen-like activity of ethanol extract of Ganoderma lucidum . J Wood Sci 55, 53–59 (2009). https://doi.org/10.1007/s10086-008-0992-2 

[6] Vargas KG, Milic J, Zaciragic A, Wen KX, Jaspers L, Nano J, Dhana K, Bramer WM, Kraja B, van Beeck E, Ikram MA, Muka T, Franco OH. The functions of estrogen receptor beta in the female brain: A systematic review. Maturitas. 2016 Nov;93:41-57. doi: 10.1016/j.maturitas.2016.05.014. Epub 2016 Jun 4. PMID: 27338976.

[7] Anuar AM, Minami A, Matsushita H, Ogino K, Fujita K, Nakao H, Kimura S, Sabaratnam V, Umehara K, Kurebayashi Y, Takahashi T, Kanazawa H, Wakatsuki A, Suzuki T, Takeuchi H. Ameliorating Effect of the Edible Mushroom Hericium erinaceus on Depressive-Like Behavior in Ovariectomized Rats. Biol Pharm Bull. 2022;45(10):1438-1443. doi: 10.1248/bpb.b22-00151. PMID: 36184501.

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[9] Ratto D, Corana F, Mannucci B, Priori EC, Cobelli F, Roda E, Ferrari B, Occhinegro A, Di Iorio C, De Luca F, Cesaroni V, Girometta C, Bottone MG, Savino E, Kawagishi H, Rossi P. Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging.Nutrients. 2019 Mar 27;11(4):715. doi: 10.3390/nu11040715. PMID: 30934760; PMCID: PMC6521003.

[10] Tsai-Teng T, Chin-Chu C, Li-Ya L, Wan-Ping C, Chung-Kuang L, Chien-Chang S, Chi-Ying HF, Chien-Chih C, Shiao YJ. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice. J Biomed Sci. 2016 Jun 27;23(1):49. doi: 10.1186/s12929-016-0266-z. PMID: 27350344; PMCID: PMC4924315.

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[15] Spim SRV, Pistila AMH, Pickler TB, Silva MT, Grotto D. Effects of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Bars on Lipid and Antioxidant Profiles in Individuals with Borderline High Cholesterol: A Double-Blind Randomized Clinical Trial. Int J Med Mushrooms. 2021;23(7):1-12. doi: 10.1615/IntJMedMushrooms.2021038773. PMID: 34375514.

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